Josephson Coupling through a Quantum Dot

We derive, via fourth order perturbation theory, an expression for the Josephson current through a gated interacting quantum dot. We analyze our expression for two different models of the superconductor-dot-superconductor (SDS) system. When the matrix elements connecting dot and leads are featureless constants, we compute the Josephson coupling J_c as a function of the gate voltage and Coulomb interaction. In the diffusive dot limit, we compute the probability distribution P(J_c) of Josephson couplings. In both cases, pi junction behavior (J_c < 0) is possible, and is not simply dependent on the parity of the dot occupancy.Comment: 9 pages; 3 encapsulated PostScript figure

Plasmodium Falciparum HRP2 Elisa for Analysis of Dried Blood Spot Samples in Rural Zambia

Background: Dried blood spots are commonly used for sample collection in clinical and non-clinical settings. This method is simple, and biomolecules in the samples remain stable for months at room temperature. In the field, blood samples for the study and diagnosis of malaria are often collected on dried blood spot cards, so development of a biomarker extraction and analysis method is needed. Methods: A simple extraction procedure for the malarial biomarker Plasmodium falciparum histidine-rich protein 2 (HRP2) from dried blood spots was optimized to achieve maximum extraction efficiency. This method was used to assess the stability of HRP2 in dried blood spots. Furthermore, 328 patient samples made available from rural Zambia were analysed for HRP2 using the developed method. These samples were collected at the initial administration of artemisinin-based combination therapy and at several points following treatment. Results: An average extraction efficiency of 70% HRP2 with a low picomolar detection limit was achieved. In specific storage conditions HRP2 was found to be stable in dried blood spots for at least 6 months. Analysis of patient samples showed the method to have a sensitivity of 94% and a specificity of 89% when compared with microscopy, and trends in HRP2 clearance after treatment were observed. Conclusions: The dried blood spot ELISA for HRP2 was found to be sensitive, specific and accurate. The method was effectively used to assess biomarker clearance characteristics in patient samples, which prove it to be ideal for gaining further insight into the disease and epidemiological applications

Evidence for Histidine-Rich Protein 2 Immune Complex Formation in Symptomatic Patients in Southern Zambia

Background: Rapid diagnostic tests based on histidine-rich protein 2 (HRP2) detection are the primary tools used to detect Plasmodium falciparum malaria infections. Recent conflicting reports call into question whether α-HRP2 antibodies are present in human host circulation and if resulting immune complexes could interfere with HRP2 detection on malaria RDTs. This study sought to determine the prevalence of immune-complexed HRP2 in a low-transmission region of Southern Zambia. Methods: An ELISA was used to quantify HRP2 in patient sample DBS extracts before and after heat-based immune complex dissociation. A pull-down assay reliant on proteins A, G, and L was developed and applied for IgG and IgM capture and subsequent immunoprecipitation of any HRP2 present in immune complexed form. A total of 104 patient samples were evaluated using both methods. Results: Immune-complexed HRP2 was detectable in 17% (18/104) of all samples evaluated and 70% (16/23) of HRP2-positive samples. A majority of the patients with samples containing immune-complexed HRP2 had P. falciparum infections (11/18) and were also positive for free HRP2 (16/18). For 72% (13/18) of patients with immune-complexed HRP2, less than 10% of the total HRP2 present was in immune-complexed form. For the remaining samples, a large proportion (≥ 20%) of total HRP2 was complexed with α-HRP2 antibodies. Conclusions: Endogenous α-HRP2 antibodies form immune complexes with HRP2 in the symptomatic patient population of a low-transmission area in rural Southern Zambia. For the majority of patients, the percentage of HRP2 in immune complexes is low and does not affect HRP2-based malaria diagnosis. However, for some patients, a significant portion of the total HRP2 was in immune-complexed form. Future studies investigating the prevalence and proportion of immune-complexed HRP2 in asymptomatic individuals with low HRP2 levels will be required to assess whether α-HRP2 antibodies affect HRP2 detection for this portion of the transmission reservoir

An analysis of integrative outcomes in the Dayton peace negotiations

The nature of the negotiated outcomes of the eight issues of the Dayton Peace Agreement was studied in terms of their integrative and distributive aspects. in cases where integrative elements were Sound, further analysis was conducted by concentrating on Pruitt's five types of integrative solutions: expanding the pie, cost cutting, non-specific compensation, logrolling, and bridging. The results showed that real world international negotiations can arrive at integrative agreements even when they involve redistribution of resources tin this case the redistribution of former Yugoslavia). Another conclusion was that an agreement can consist of several distributive outcomes and several integrative outcomes produced by different kinds of mechanisms. Similarly, in single issues more than one mechanism can be used simultaneously. Some distributive bargaining was needed in order to determine how much compensation was required. Finally, each integrative formula had some distributive aspects as well

Random tree growth by vertex splitting

We study a model of growing planar tree graphs where in each time step we separate the tree into two components by splitting a vertex and then connect the two pieces by inserting a new link between the daughter vertices. This model generalises the preferential attachment model and Ford's $\alpha$-model for phylogenetic trees. We develop a mean field theory for the vertex degree distribution, prove that the mean field theory is exact in some special cases and check that it agrees with numerical simulations in general. We calculate various correlation functions and show that the intrinsic Hausdorff dimension can vary from one to infinity, depending on the parameters of the model.Comment: 47 page

Many Body Theory of Charge Transfer in Hyperthermal Atomic Scattering

We use the Newns-Anderson Hamiltonian to describe many-body electronic processes that occur when hyperthermal alkali atoms scatter off metallic surfaces. Following Brako and Newns, we expand the electronic many-body wavefunction in the number of particle-hole pairs (we keep terms up to and including a single particle-hole pair). We extend their earlier work by including level crossings, excited neutrals and negative ions. The full set of equations of motion are integrated numerically, without further approximations, to obtain the many-body amplitudes as a function of time. The velocity and work-function dependence of final state quantities such as the distribution of ion charges and excited atomic occupancies are compared with experiment. In particular, experiments that scatter alkali ions off clean Cu(001) surfaces in the energy range 5 to 1600 eV constrain the theory quantitatively. The neutralization probability of Na$^+$ ions shows a minimum at intermediate velocity in agreement with the theory. This behavior contrasts with that of K$^+$, which shows ... (7 figures, not included. Figure requests: [email protected])Comment: 43 pages, plain TeX, BUP-JBM-

Blended wing body with boundary layer ingestion conceptual design in a multidisciplinary design analysis optimization environment

This paper introduces the GENUS multidisciplinary concept level aircraft design and analysis environment developed by Cranfield University in recent years and it has been applied to the conceptual design of blended wing body (BWB) aircraft. Analytical disciplines include a variety of low-to-medium fidelity, physics-based and empirical methods, and aerodynamic analysis of high-order panel method. Boundary layer ingestion (BLI), as a special module, has been incorporated into the aerodynamic and propulsion analysis. The results of the Cranfield BW-11 are presented. In the highly-constrained design space, a type of highly fuel- efficient BWB concept can be studied, and the advantages of the BLI concept can also be explored based on this framework

Adam Sandler as (questionable) masculine ‘role model’: towards an analysis of disgust and violence in Adam Sandler's comedian comedy

© 2018 Informa UK Limited, trading as Taylor & Francis Group Adam Sandler's film work has been critically vilified and paid little attention by academics. This article suggests that his work justifies sustained academic attention, yet I conclude that he offers questionable masculine role models dependent on masculinity being asserted via ambivalent dis-identification with gay men and women. I argue this case via critique of the most sustained analyses of his workand via close readings of aspects of Sandler's films. I dispute Chapman's contextualisation of Sandler's film comedies in relation to thinking about masculinity and gay men. These changes have arisen in response to feminism and the lesbian and gay movement. I argue that Chapman's contextualisation of, and the ambiguities of Sandler's engagement with, feminism and gay men needs more critical attention. Further, I argue that we should actively read Sandler's films using Seidman's idea of comedian comedy and that focusing attention on such comedies’ tensions with narrative film enable us to direct our critical attention on the ambivalences present in Sandler's movies. His films show resistance to relinquishing some privileges of dominant forms of masculinity (physical violence) and demonstrate disgust withthe sexuality, bodies and behaviour of gay men